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KMID : 0984920080100010003
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Journal of Skin Barrier Research
2008 Volume.10 No. 1 p.3 ~ p.9
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Biology of stratum corneum: tape stripping and protein quantification
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Ali Alikhan
Howard I. Maibach
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Abstract
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Spanning a half century, tape stripping is an effective, relatively noninvasive method to harvest stratum corneum, calculate its thickness in vivo, and determine the penetration of topical agents. Several methods to quantify protein have been described. These include traditional gravimetric methods, as well as novel colorimetric and visible spectroscopic techniques. Recently, a colorimetric method was effectively utilized to determine keratolytic efficacy in vivo, further demonstrating endless roles for this tried-but-true method. Much remains to be learned about the roles of this thin but functionally complex membrane.
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KEYWORD
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tape stripping, stratum corneum, noninvasive, protein, quantification
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